Within Dr. Lewis' laboratory, this general translational research strategy is employed to focus on understanding the organization and the functional properties of the neural circuitry of the prefrontal cortex and interconnected brain regions, and the alterations of this circuitry in schizophrenia. These investigations involve 6 components:
  1. The architecture and connectivity of the primate neocortex
  2. The postnatal development of this circuitry
  3. The functional properties mediated by this circuitry
  4. The disturbances of this circuitry in schizophrenia
  5. Experimental tests of the pathogenesis and pathophysiology of these circuitry disturbances
  6. Development of novel interventions predicted to improve circuitry function in individuals with schizophrenia

• Translational Neuroscience Program •
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David A. Lewis, M.D. | Department of Psychiatry | University of Pittsburgh
3811 O'Hara Street, Biomedical Science Tower W1654
Pittsburgh, Pennsylvania 15213-2593
Phone: (412) 624-3894 - Fax: (412) 624-9910