Within Dr. Lewis' laboratory, this general translational research strategy
is employed to focus on understanding the organization and the functional
properties of the neural circuitry of the prefrontal cortex and interconnected
brain regions, and the alterations of this circuitry in schizophrenia. These
investigations involve six components: 1) The normal functional architecture
of the primate neocortex; 2) The postnatal development of this circuitry;
3) The cognitive functions mediated by this circuitry; 4) The disturbances of this circuitry in schizophrenia; 5) Experimental tests
of the pathogenesis and pathophysiology of these circuitry disturbances; and
6) Clinical trials of novel compounds predicted to improve prefrontal dysfunction
in individuals with schizophrenia.







