Within Dr. Lewis' laboratory, this general translational research strategy is employed to focus on understanding the organization and the functional properties of the neural circuitry of the prefrontal cortex and interconnected brain regions, and the alterations of this circuitry in schizophrenia. These investigations involve six components: 1) The normal functional architecture of the primate neocortex; 2) The postnatal development of this circuitry; 3) The cognitive functions mediated by this circuitry; 4) The disturbances of this circuitry in schizophrenia; 5) Experimental tests of the pathogenesis and pathophysiology of these circuitry disturbances; and 6) Clinical trials of novel compounds predicted to improve prefrontal dysfunction in individuals with schizophrenia.