Selected Publications Title
 
For a selection of review articles that provides an introduction to research in the Lewis Lab, see the Lewis Lab Primer
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NOTE: The incorporated links to full-text journal articles are available only to users at institutions that have e-Journal subscriptions.

  • Georgiev G, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, Lewis DA, Hashimoto T: Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia. Am J Psychiatry 171:62-71, 2014. (Full Text PDF)

  • Glausier JR, Fish KN, Lewis DA: Altered parvalbumin basket cell inputs in the dorsolateral prefrontal cortex of schizophrenia subjects. Mol Psychiatry 19:30-36, 2014. (Full Text PDF)

  • Cho RY, Walker CP, Polizzotto NR, Wozny TA, Fissell C, Chen CA, Lewis DA: Development of sensory gamma oscillations and cross-frequency coupling from childhood to early adulthood. Cerebral Cortex, ePub December 10, 2013. (Full Text PDF)

  • Povysheva NV, Zaitsev AV, Gonzalez-Burgos G, Lewis DA: Electrophysiological heterogeneity of fast-spiking interneurons: Chandelier versus basket cells. PLoS One 8:e70553, 2013. (Full Text PDF)

  • Pafundo DE, Miyamae T, Lewis DA, Gonzalez-Burgos G: Cholinergic modulation of neuronal excitability and recurrent excitation-inhibition in prefrontal cortex circuits: Implications for gamma oscillations. J Physiol 591:4725-4748, 2013. (Full Text PDF)

  • Siegel BI, Sengupta EJ, Edelson JR, Lewis DA, Volk DW: Elevated viral restriction factor levels in cortical blood vessels in schizophrenia. Biol Psychiatry, ePub September 30, 2013. (Full Text PDF)

  • Verrico CD, Gu H, Peterson ML, Sampson AR, Lewis DA.  Repeated Δ9-tetrahydrocannabinol exposure in adolescent monkeys: Persistent effects selective for spatial working memory. Am J Psychiatry 171 (4):416-425. (Full Text PDF)

  • Volk DW, Siegel BI, Verrico CD, Lewis DA: Endocannabinoid metabolism in the prefrontal cortex in schizophrenia. Schizophr Res 147:53-57, 2013. (Full Text PDF)

  • Volk DW and Lewis DA: Prenatal ontogeny as a susceptibility period for cortical GABA neuron disturbances in schizophrenia. Neuroscience, ePub June 13, 2013. (Full Text PDF)

  • Fish KN, Hoftman G, Sheikh W, Kitchens M, Lewis DA: Parvalbumin-containing chandelier and basket cell boutons have distinctive modes of maturation in monkey prefrontal cortex. J Neurosci, 33:8352-8358, 2013. (Full Text PDF)

  • Glausier JR and Lewis DA: Dendritic spine pathology in schizophrenia. Neuroscience, ePub April 27, 2012. (Full Text PDF)

  • Curley AA, Eggan SM, Lazarus MS, Huang ZJ, Volk DW, Lewis DA: Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: Implications for schizophrenia. Neurobiol Dis 50:179-86, 2013. (Full Text PDF)

  • Gonzalez-Burgos G and Lewis DA: NMDA receptor hypofunction, parvalbumin-positive neurons and cortical gamma oscillations in schizophrenia. Schizophr Bull 38:950-957, 2012. (Full Text PDF)

  • Georgiev D, Gonzalez-Burgos G, Minabe Y, Lewis DA, Hashimoto T: Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex. PLoS One 7:e43904, 2012. (Full Text PDF)

  • Volk DW, Matsubara T, Li S, Sengupta EJ, Georgiev D, Minabe Y, Sampson A, Hashimoto T, Lewis DA: Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia. Am J Psychiatry, 169: 1082-1091, 2012. (Full Text PDF)

  • Verrico CD, Liu S, Bitler EJ, Gu H, Sampson AR, Bradberry CW, Lewis DA: Delay- and dose-dependent effects of Δ9-Tetrahydrocannabinol administration on spatial and object working memory tasks in adolescent rhesus monkeys. Neuropsychopharmacology 37(6):1357-66, 2012. (Full Text PDF)

  • Curley AA, Lewis DA: Cortical basket cell dysfunction in schizophrenia. J Physiol 590(Pt 4):715-724, 2012. (Full Text PDF)

  • Lewis DA, Curley AA, Glausier JR, Volk DW: Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia. Trends Neurosci 35(1):57-67, 2012. (Full Text PDF)

  • Eggan SM, Lazarus MS, Stoyak SR, Volk DW, Glausier JR, Huang J, Lewis DA: Cortical GAD67 deficiency results in lower cannabinoid 1 receptor mRNA expression: Implications for schizophrenia. Biol Psychiatry 71(2):114-9, 2012. (Full Text PDF)

  • Lewis DA: Pharmacological enhancement of cognition in individuals with schizophrenia. Biol Psychiatry 69:397-398, 2011. (Full Text PDF)

  • Lewis DA: Antipsychotic medications and brain volume: Do we have cause for concern? Arch Gen Psychiatry 68:126-127, 2011. (Full Text PDF)

  • Volk, DW Radchenkova PV, Walker EM, Sengupta EJ, Lewis DA: Cortical opioid markers in schizophrenia and across postnatal development. Cereb Cortex 22(5):1215-23, 2012. (Full Text PDF)

  • Beneyto M, Morris HM, Rovensky KC, Lewis DA: Lamina- and cell-specific alterations in cortical somatostatin receptor 2 mRNA expression in schizophrenia. Neuropharmacology 62(3):1598-605, 2012. (Full Text PDF)

  • Yoshino H, Miyamae T, Hansen G, Zambrowicz B, Flynn M, Pedicord D, Blat Y, Westphal RS, Zaczek R, Lewis DA, Gonzalez-Burgos G: Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. J Physiol 589:4857-4884, 2011. (Full Text PDF)

  • Glausier JR and Lewis DA: Selective pyramidal cell reduction of GABAA receptor a1 subunit messenger RNA expression in schizophrenia. Neuropsychopharmacology 36:2103-2110, 2011. (Full Text PDF)

  • Lewis DA, Fish KN, Arion D, Gonzalez-Burgos G: Perisomatic inhibition and cortical circuit dysfunction in schizophrenia. Curr Opin Neurobiol 21(6):866-72, 2011. (Full Text PDF)

  • Curley AA, Arion D, Volk DW, Asafu-Adjei JK, Sampson AR, Fish KN, Lewis DA: Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: clinical, protein, and cell type-specific features. Am J Psychiatry 168:921-929, 2011. (Full Text PDF)

  • Fish KN, Sweet RA, Lewis DA: Differential distribution of proteins regulating GABA synthesis and reuptake in axon boutons of subpopulations of cortical interneurons. Cereb Cortex 21:2450-2460, 2011. (Full Text PDF)

  • Hoftman GD, Lewis DA: Postnatal developmental trajectories of neural circuits in the primate prefrontal cortex: identifying sensitive periods for vulnerability to schizophrenia. Schizophr Bull 37(3):493-503, 2011. (Full Text PDF)

  • Rotaru DC, Yoshino H, Lewis DA, Ermentrout GB, Gonzalez-Burgos G: Glutamate receptor subtypes mediating synaptic activation of prefrontal cortex neurons: relevance for schizophrenia. J Neurosci 31:142-156, 2011. (Full Text PDF)

  • Sibille E, Morris HM, Kota RS, Lewis DA: GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders. Int J Neuropsychopharmacol 14:721-734, 2011. (Full Text PDF)

  • Beneyto M, Abbott A, Hashimoto T, Lewis DA: Lamina-specific alterations in cortical GABAA receptor subunit expression in schizophrenia. Cereb Cortex 21:999-1011, 2011. (Full Text PDF)

  • Verrico CD, Liu S, Asafu-Adjei JK, Sampson AR, Bradberry CW, Lewis DA: Acquisition and baseline performance of working memory tasks by adolescent rhesus monkeys. Brain Res 1378:91-104, 2011. (Full Text PDF)

  • Lewis DA: The chandelier neuron in schizophrenia. Dev Neurobiol 71:118-127, 2011. (Full Text PDF)

  • Dorph-Petersen KA and Lewis DA: Stereological approaches to identifying neuropathology in psychosis. Biol Psychiatry 69:113-126, 2011. (Full Text PDF)

  • Arion D and Lewis DA: Altered expression of regulators of the cortical choloride transporters NKCC1 and KCC2 in schizophrenia. Arch Gen Psychiatry 68:21-31, 2011. (Full Text PDF)

  • Volk DW, Eggan SM, Lewis DA: Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia. Am J Psychiatry 167: 1489-1498, 2010. (Full Text PDF)

  • Eggan SM, Stoyak SR, Verrico CD, Lewis DA: Cannabinoid CB1 receptor immunoreactivity in the prefrontal cortex: comparison of schizophrenia and major depressive disorder. Neuropsychopharmacol 35:2060-2071, 2010. (Full Text PDF)

  • Ide M and Lewis DA: Altered cortical CDC42 signaling pathways in schizophrenia: Implications for dendritic spine deficits. Biol Psychiatry 68:25-32, 2010. (Full Text PDF)

  • Eggan SM, Mizoguchi Y, Stoyak SR, Lewis DA: Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex. Cereb Cortex 20:1164-1174, 2010. (Full Text PDF)

  • Cruz DA, Weaver CL, Lovallo EM, Melchitzky DS, Lewis DA: Selective alterations in postsynaptic markers of chandelier cell inputs to cortical pyramidal neurons in subjects with schizophrenia. Neuropsychopharmacology 34: 2112-2124, 2009. (Full Text PDF)

  • Zaitsev AV, Povysheva NV, Gonzalez-Burgos G, Rotaru D, Fish KN, Krimer LS, Lewis DA: Interneuron diversity in layers 2-3 of monkey prefrontal cortex. Cereb Cortex 19:1597-1615, 2009. (Full Text PDF)

  • Hashimoto T, Nguyen QL, Rotaru D, Keenan T, Arion D, Beneyto M, Gonzalez-Burgos G, and Lewis DA: Protracted developmental trajectories of GABAA receptor α1 and α2 subunit expression in primate prefrontal cortex. Biol Psychiatry 65:1015–1023, 2009. (Full Text PDF)

  • Maldonado-Avilés JG, Curley AA, Hashimoto T, Morrow AL, Ramsey AJ, O'Donnell P, Volk DW, Lewis DA: Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia. Am J Psychiatry 166: 450-459, 2009. (Full Text PDF)

  • Lewis DA and Sweet RA: Schizophrenia from a neural circuitry perspective: Advancing toward rational pharmacological therapies. J Clin Invest 119: 706-716, 2009. (Full Text PDF)

  • Cruz DA, Lovallo EM, Stockton S, Rasband M, Lewis DA: Postnatal development of synaptic structure proteins in pyramidal neuron axon initial segments in monkey prefrontal cortex. J Comp Neurol 514: 353–367, 2009. (Full Text PDF)

  • Gonzalez-Burgos G, Rotaru DC, Zaitsev AV, Povysheva NV, Lewis DA: GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons. J Neurophysiol 101: 533–547, 2009. (Full Text PDF)

  • Lewis DA, Cho RY, Carter CS, Eklund K, Forster S, Kelly MA, Montrose D: Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia. Am J Psychiatry 165: 1585-1593, 2008. (Full Text PDF)

  • Gonzalez-Burgos G, Lewis DA: GABA neurons and the mechanisms of network oscillations: Implications for understanding cortical dysfunction in schizophrenia. Schizophr Bull 34: 944-961, 2008. (Full Text PDF)

  • Eggan SM, Hashimoto T, Lewis DA: Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. Arch Gen Psychiatry 65: 772-784, 2008. (Full Text PDF)

  • Morris HM, Hashimoto T, Lewis DA: Alterations in somatostatin mRNA expression in the dorsolateral prefrontal cortex of subjects with schizophrenia or schizoaffective disorder. Cereb Cortex 18: 1575-1587, 2008. (Full Text PDF)

  • Konopaske GT, Dorph-Petersen K-A, Sweet RA, Pierri JN, Zhang W, Sampson AR, Lewis DA: Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biol Psychiatry 63: 759-765, 2008. (Full Text PDF)

  • Hashimoto T, Bazmi HH, Mirnics K, Wu Q, Sampson AR, Lewis DA: Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am J Psychiatry 165: 479-489, 2008. (Full Text PDF)

  • Gonzalez-Burgos G, Kröner S, Zaitsev A, Povysheva N, Krimer L, Barrionuevo G, Lewis DA: Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex. Cereb Cortex 18: 626-637, 2008. (Full Text PDF)

  • Hashimoto T, Arion D, Unger T, Maldonado-Aviles JG, Morris HM, Volk DW, Mirnics K, Lewis DA: Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 13: 147-161, 2008. (Full Text PDF)

  • Lewis DA, Gonzalez-Burgos G: Neuroplasticity of neocortical circuits in schizophrenia. Neuropsychopharmacology Reviews 33: 141-165, 2008. (Full Text PDF)

  • Eggan SM, Lewis DA: Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate cerebral cortex: A regional and laminar analysis. Cereb Cortex 17:175-191. 2007. (Full Text PDF)

  • Lewis DA, Gonzalez-Burgos G: Pathophysiologically based treatment interventions in schizophrenia. Nat Med 12:1016-1022, 2006. (Full Text PDF)

  • Mirnics K, Levitt P, Lewis DA: Critical appraisal of DNA microarrays in psychiatric genomics. Biol Psychiatry 60(2):163-176, 2006. (Full Text PDF)

  • Hill JJ, Hashimoto T, Lewis DA: Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 11:557-566, 2006. (Full Text PDF)

  • Krimer LS, Zaitsev AV, Czanner G, Kröner S, González-Burgos G, Povysheva NV, Iyengar S, Barrionuevo G, Lewis DA: Cluster analysis-based physiological classification and morphological properties of inhibitory neurons in layers 2-3 of monkey dorsolateral prefrontal cortex. J Neurophysiol 94:3009-3022, 2005. (Full Text PDF)

  • Dorph-Petersen K-A, Pierri JN, Perel JM, Sun Z, Sampson AR, Lewis DA: The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: A comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology 30:1649-1661, 2005. (Full Text PDF)

  • Kolluri N, Sun Z, Sampson A, Lewis DA: Lamina-specific reductions in dendritic spine density in the prefrontal cortex of subjects with schizophrenia. Am J Psychiatry 162:1203-1205, 2005. (Full Text PDF)

  • Lewis DA, Hashimoto T, Volk DW: Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci 6:312-324, 2005. (Full Text PDF)

  • González-Burgos G, Krimer LS, Povysheva NV, Barrionuevo G, Lewis DA: Functional properties of fast spiking interneurons and their synaptic connections with pyramidal cells in primate dorsolateral prefrontal cortex. J Neurophysiology 93:942-953, 2005. (Full Text PDF)

  • Hashimoto T, Bergen SE, Nguyen, Q, Xu B, Monteggia LM, Pierri JN, Sun Z, Sampson AR, Lewis DA: Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 25:372-383, 2005. (Full Text PDF)

  • González-Burgos G, Krimer LS, Urban NN, Barrionuevo G, Lewis DA: Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortex. Cereb Cortex 14:530-542, 2004. (Full Text PDF)

  • Hashimoto T, Volk DW, Eggan SM, Mirnics K, Pierri JN, Sun Z, Sampson AR, Lewis DA: Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci 23:6315-6326, 2003. (Full Text PDF)

  • Lewis DA, Levitt P: Schizophrenia as a disorder of neurodevelopment. Ann Rev Neurosci 25:409-432, 2002. (Full Text PDF)

  • Volk DW, Pierri JN, Fritschy J-N, Auh S, Sampson AR, Lewis DA: Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia. Cereb Cortex 12:1063-1070, 2002. (Full Text PDF)

  • Pierri JN, Volk CLE, Auh S, Sampson AR, Lewis DA: Decreased somal size of deep layer 3 pyramidal neurons in the prefrontal cortex in subjects with schizophrenia. Arch Gen Psychiatry 58:466-473, 2001. (Full Text PDF)

  • Lewis DA and Lieberman JA: Catching up on schizophrenia: Natural history and neurobiology. Neuron 28:325-334, 2000. (Full Text PDF)

  • Mirnics K, Middleton F, Marquez A, Lewis DA, Levitt P: Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 28:53-67, 2000. (Full Text PDF)

  • Volk DW, Austin MC, Pierri JN, Sampson AR, Lewis DA: Decreased GAD67 mRNA expression in a subset of prefrontal cortical GABA neurons in subjects with schizophrenia. Arch Gen Psychiatry 57:237-245, 2000. (Full Text PDF)

  • Glantz LA, Lewis DA: Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry 57:65-73, 2000. (Full Text PDF)

  • Pierri JN, Chaudry AS, Woo T-U, Lewis DA: Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenic subjects. Am J Psychiatry 156:1709-1719, 1999. (Full Text PDF)

  • Akil M, Pierri JN, Whitehead RE, Edgar CL, Mohila C, Sampson AR, Lewis DA: Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects. Am J Psychiatry 156:1580-1589, 1999. (Full Text PDF)

  • Woo T-U, Whitehead RE, Melchitzky DS, Lewis DA: A subclass of prefrontal -aminobutyric acid axon terminals are selectively altered in schizophrenia. Proc Natl Acad Sci USA 95:5341-5346, 1998. (Full Text PDF)




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David A. Lewis, M.D. | Department of Psychiatry | University of Pittsburgh
3811 O'Hara Street, Biomedical Science Tower W1654
Pittsburgh, Pennsylvania 15213-2593
Phone: (412) 383-8548 - Fax: (412) 624-9910