NOTE: The incorporated links to full-text journal articles are available only to users at institutions that have e-Journal subscriptions.

• Hashimoto T, Nguyen QL, Rotaru D, Keenan T, Arion D, Beneyto M, Gonzalez-Burgos G, and Lewis DA: Protracted developmental trajectories of GABA_A receptor α1 and α2 subunit expression in primate prefrontal cortex. Biol Psychiatry 65:1015–1023, 2009. (Full Text PDF)
  
  
• Lewis DA and Sweet RA: Schizophrenia from a neural circuitry perspective: Advancing toward rational pharmacological therapies. J Clin Invest 119: 706-716, 2009. (Full Text PDF)
  
  
• Cruz DA, Lovallo EM, Stockton S, Rasband M, Lewis DA: Postnatal development of synaptic structure proteins in pyramidal neuron axon initial segments in monkey prefrontal cortex. J Comp Neurol 514: 353–367, 2009. (Full Text PDF)
  
  
• Cruz DA, Weaver CL, Lovallo EM, Melchitzky DS, Lewis DA: Selective alterations in postsynaptic markers of chandelier cell inputs to cortical pyramidal neurons in subjects with schizophrenia. Neuropsychopharmacology, 34: 2112-2124, 2009. (Full Text PDF)
  
  
• Maldonado-Avilés JG, Curley AA, Hashimoto T, Morrow AL, Ramsey AJ, O’Donnell P, Volk DW, Lewis DA: Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia. Am J Psychiatry 166: 450-459, 2009. (Full Text PDF)
  
  
• Gonzalez-Burgos G, Rotaru DC, Zaitsev AV, Povysheva NV, Lewis DA: GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons. J Neurophysiol 101: 533–547, 2009. (Full Text PDF)
  
  
• Povysheva NV, Zaitsev AV, Rotaru DC, Gonzalez-Burgos G, Lewis DA, Krimer LS: Parvalbumin-positive basket interneurons in monkey and rat prefrontal cortex. J Neurophysiol 100: 2348–2360, 2008. (Full Text PDF)
  
  
• Zaitsev AV, Povysheva NV, Gonzalez-Burgos G, Rotaru D, Fish KN, Krimer LS, Lewis DA: Interneuron diversity in layers 2-3 of monkey prefrontal cortex. Cereb Cortex 19:1597-1615, 2009. (Full Text PDF)
  
  
• Lewis DA, Cho RY, Carter CS, Eklund K, Forster S, Kelly MA, Montrose D: Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia. Am J Psychiatry 165: 1585-1593, 2008. (Full Text PDF)
  
  
• Fish KN, Sweet RA, Deo AJ, Lewis DA: An automated segmentation methodology for quantifying immunoreactive puncta number and fluorescence intensity in tissue sections. Brain Res 1240: 62-72, 2008. (Full Text PDF)
  
  
• Melchitzky D, Lewis DA: Dendritic-targeting GABA neurons in monkey prefrontal cortex: Comparison of somatostatin- and calretinin-immunoreactive axon terminals. Synapse 62: 456-465, 2008. (Full Text PDF)
  
  
• Eggan SM, Hashimoto T, Lewis DA: Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. Arch Gen Psychiatry 65: 772-784, 2008. (Full Text PDF)
  
  
• Gonzalez-Burgos G, Lewis DA: GABA neurons and the mechanisms of network oscillations: Implications for understanding cortical dysfunction in schizophrenia. Schiz Bull 34: 944-961, 2008. (Full Text PDF)
  
  
• Lewis DA, Gonzalez-Burgos G: Neuroplasticity of neocortical circuits in schizophrenia. Neuropsychopharmacology Reviews 33: 141-165, 2008. (Full Text PDF)
  
  
• Hashimoto T, Arion D, Unger T, Maldonado-Aviles JG, Morris HM, Volk DW, Mirnics K, Lewis DA: Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 13: 147-161, 2008. (Full Text + Links)
  
  
• Gonzalez-Burgos G, Kröner S, Zaitsev A, Povysheva N, Krimer L, Barrionuevo G, Lewis DA: Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex. Cereb Cortex, 18: 626-637, 2008. (Full Text PDF)
  
  
• Hashimoto T, Bazmi HH, Mirnics K, Wu Q, Sampson AR, Lewis DA: Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am J Psychiatry 165: 479-489, 2008. (Full Text PDF)
  
  
• Konopaske GT, Dorph-Petersen K-A, Sweet RA, Pierri JN, Zhang W, Sampson AR, Lewis DA: Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biol Psychiatry 63: 759-765, 2008. (Full Text + Links)
  
  
• Morris HM, Hashimoto T, Lewis DA: Alterations in somatostatin mRNA expression in the dorsolateral prefrontal cortex of subjects with schizophrenia or schizoaffective disorder. Cereb Cortex 18: 1575-1587, 2008. (Full Text PDF)
  
  
• Eggan SM, Lewis DA: Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate cerebral cortex: A regional and laminar analysis. Cereb Cortex 17:175-191. 2007. (Full Text PDF)
  
  
• Melchitzky DS, Erickson SL, Lewis DA: Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals. Neuroscience, 143:1021-1030, 2006. (Full Text + Links)
  
  
• Lewis DA, Moghaddam B: Cognitive dysfunction in schizophrenia: Convergence of GABA and glutamate alterations. Arch Neurol 63:1372-1376, 2006. (Full Text PDF)
  
  
• Levitt P, Ebert P, Mirnics K, Nimgaonkar VL, Lewis DA: Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4(RGS4). Biol Psych 60:534-537, 2006. (Full Text + Links)
  
  
• Lewis DA, Gonzalez-Burgos G: Pathophysiologically based treatment interventions in schizophrenia. Nature Medicine 12:1016-1022, 2006. (Full Text PDF)
  
  
• Mirnics K, Levitt P, Lewis DA: Critical appraisal of DNA microarrays in psychiatric genomics. Biol Psychiatry 60(2):163-176, 2006. (Abstract)

• Maldonado-Avilés JG, Wu Q, Sampson AR, Lewis DA: Somal size of immunolabeled pyramidal cells in the prefrontal cortex of subjects with schizophrenia. Biol Psychiatry 60(3):226-34, 2006. (Abstract)

• Hill JJ, Hashimoto T, Lewis DA: Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 11:557-566, 2006. (Full Text PDF)

• Hashimoto T, Lewis DA: BDNF Val66Met Polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophrenia. Am J Psychiatry 163(3):534-537, 2006. (Full Text PDF)

• Konopaske GT, Sweet RA, Wu Q, Sampson AR, Lewis DA: Regional specificity of chandelier neuron axon terminal alterations in schizophrenia. Neuroscience 138:189-196, 2006. (Full Text PDF)

• Krimer LS, Zaitsev AV, Czanner G, Kröner S, González-Burgos G, Povysheva NV, Iyengar S, Barrionuevo G, Lewis DA: Cluster analysis-based physiological classification and morphological properties of inhibitory neurons in layers 2-3 of monkey dorsolateral prefrontal cortex. J Neurophysiol 94:3009-3022, 2005. (Full Text PDF)

• Sweet RA, Dorph-Petersen KA, Lewis DA: Mapping auditory core, lateral belt, and parabelt cortices in the human superior temporal gyrus. J Comp Neurol 491:270-289, 2005. (Full Text PDF)

• Dorph-Petersen K-A, Pierri JN, Perel JM, Sun Z, Sampson AR, Lewis DA: The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: A comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology 30:1649-1661, 2005. (Full Text PDF)

• Lewis DA, Mirnics K, Levitt P: Gene expression changes in schizophrenia: How do they arise? What do they mean? Clin Neurosci Res 5:15-21, 2005. (Abstract)

• Dorph-Petersen K-A, Pierri JN, Perel JM, Sun Z, Sampson AR, Lewis DA: The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: A comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology 30:1649-1661, 2005. (Full Text PDF)

• Kolluri N, Sun Z, Sampson A, Lewis DA: Lamina-specific reductions in dendritic spine density in the prefrontal cortex of subjects with schizophrenia. Am J Psychiatry 162:1203-1205, 2005. (Full Text PDF)

• Lewis DA, Hashimoto T, Volk DW: Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci 6:312-324, 2005. (Full Text PDF)

• González-Burgos G, Krimer LS, Povysheva NV, Barrionuevo G, Lewis DA: Functional properties of fast spiking interneurons and their synaptic connections with pyramidal cells in primate dorsolateral prefrontal cortex. J Neurophysiology 93:942-953, 2005. (Full Text PDF)

• Hashimoto T, Bergen SE, Nguyen, Q, Xu B, Monteggia LM, Pierri JN, Sun Z, Sampson AR, Lewis DA: Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 25:372-383, 2005. (Full Text PDF)

• Melchitzky DS, Eggan SM, Lewis DA: Synaptic targets of calretinin-containing axon terminals in macaque monkey prefrontal cortex. Neuroscience 130:185-195, 2005. (PubMed Abstract)

• Lewis DA, Volk DW, Hashimoto T: Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: A novel target for the treatment of working memory dysfunction. Psychopharm 174:143-150, 2004. (Full Text PDF)

• Erickson SE, Lewis DA: Cortical connections of the lateral mediodorsal thalamus in cynomolgus monkeys. J Comp Neurol 473:107-127, 2004. (Full Text PDF)

• González-Burgos G, Krimer LS, Urban NN, Barrionuevo G, Lewis DA: Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortex. Cereb Cortex 14:530-542, 2004. (Full Text PDF)

• Dorph-Petersen K-A, Pierri JN, Zhuoxin S, Sampson AR, Lewis DA: Stereological analysis of the mediodorsal thalamic nucleus in schizophrenia: Volume, neuron number, and cell types. J Comp Neurol 472:449-462, 2004. (Full Text PDF)

• Cruz DA, Eggan SM, Lewis DA: Postnatal development of pre- and post-synaptic GABA markers at chandelier cell connections with pyramidal neurons in monkey prefrontal cortex. J Comp Neurol 465:385-400, 2003. (Full Text PDF)

• Hashimoto T, Volk DW, Eggan SM, Mirnics K, Pierri JN, Sun Z, Sampson AR, Lewis DA: Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci 23:6315-6326, 2003. (Full Text PDF)

• Melchitzky DS, Lewis DA: Pyramidal neuron local axon terminals in monkey prefrontal cortex: Differential targeting of subclasses of GABA neurons. Cereb Cortex 13:452-460, 2003. (Full Text PDF)

• Sweet RA, Pierri JN, Auh S, Sampson AR, Lewis DA: Reduced pyramidal cell somal volume in auditory association cortex of subjects with schizophrenia. Neuropsychopharmacology 28:599-609, 2003. (Full Text PDF)

• Lewis DA, Levitt P: Schizophrenia as a disorder of neurodevelopment. Ann Rev Neurosci 25:409-432, 2002. (Full Text PDF)

• Volk DW, Pierri JN, Fritschy J-N, Auh S, Sampson AR, Lewis DA: Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia. Cereb Cortex 12:1063-1070, 2002. (Full Text PDF)

• Pierri JN, Volk CLE, Auh S, Sampson AR, Lewis DA: Decreased somal size of deep layer 3 pyramidal neurons in the prefrontal cortex in subjects with schizophrenia. Arch Gen Psychiatry 58:466-473, 2001. (Full Text PDF)

• Lewis DA and Lieberman JA: Catching up on schizophrenia: Natural history and neurobiology. Neuron 28:325-334, 2000. (Full Text PDF)

• Mirnics K, Middleton F, Marquez A, Lewis DA, Levitt P: Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 28:53-67, 2000. (Full Text PDF)

• Volk DW, Austin MC, Pierri JN, Sampson AR, Lewis DA: Decreased GAD67 mRNA expression in a subset of prefrontal cortical GABA neurons in subjects with schizophrenia. Arch Gen Psychiatry 57:237-245, 2000. (Full Text PDF)

• Glantz LA, Lewis DA: Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry 57:65-73, 2000. (Full Text PDF)

• Pierri JN, Chaudry AS, Woo T-U, Lewis DA: Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenic subjects. Am J Psychiatry 156:1709-1719, 1999. (Full Text PDF)

• Akil M, Pierri JN, Whitehead RE, Edgar CL, Mohila C, Sampson AR, Lewis DA: Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects. Am J Psychiatry 156:1580-1589, 1999. (Full Text PDF)

• Woo T-U, Whitehead RE, Melchitzky DS, Lewis DA: A subclass of prefrontal -aminobutyric acid axon terminals are selectively altered in schizophrenia. Proc Natl Acad Sci USA 95:5341-5346, 1998. (Full Text PDF)